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ADHD OTC Medication ADHD medication can help manage symptoms and improve the quality of life for a child or an adult. However, it's important to be aware of the adverse effects associated with medication. Stimulants increase the communication between brain's nerves. They also reduce hyperactivity, impulsivity and irritability. They are classified as controlled substances because of their potential misuse. Methylphenidate Methylphenidate can be used to treat both ADHD