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The biochemical parameters (blood glucose, body weight, Scr, BUN, UA, U-Alb and UAE) had been analyzed. The pathological changes in renal structure had been observed by histological staining with HE and Masson. The effect of EHF from the proliferation of NRK-49F cells was examined by CCK-8 assay andosis associated with structure. These conclusions might have clinical ramifications for the treatment of DN. Copyright © 2020 Shen, Jiang, Li, Wang, Ma, Zhang, Zhu, Rahman, Zhang, Luan and Zhang