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Contrast-induced artefact was assessed by observer scoring. Results Both contrast agents significantly improved the consistency of oesophagus localisation on CBCT across all comparison metrics compared to CBCTs without contrast. Barium performed significantly better than Gastrografin with improved kappa statistics (p = 0.007), dice coefficients (p less then 0.001) and Hausdorff distances (p = 0.002), although at a cost of increased image artefact. Discussion Barium produced lower delineation uncertainties but more image artefact, compa