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erogeneity. In conclusion, the results presented here showed that the dynamics of microbial fermentation can be used to identify the sources of variability and evidence the need for better fermentation technologies that favor the production of reproducible high-quality cocoa beans. Copyright © 2020 Pacheco-Montealegre, Dávila-Mora, Botero-Rute, Reyes and Caro-Quintero.We consider the problem of incorporating evolutionary information (e.g., taxonomic or phylogenic trees) in the context of metagenomics differential analysis. Recent re