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Prostate-specific membrane layer antigen PET/CT imaging revealed no irregular uptake for the prostate. Nevertheless, along with PSMA uptake in the remaining lung, thorax, and right ilium, that has been verified being a lung squamous cellular carcinoma by a lung biopsy, widespread uptake has also been noticed in their skin fibroma lesions. This case demonstrates that harmless neurofibromatosis might have uptake of PSMA.Yolk sac tumor is a rare