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Despite maximum surgical resection and chemoradiation, glioblastoma (GBM) is still associated with considerable morbidity and death. Novel therapeutic methods tend to be urgently needed. Offered success in dealing with numerous other types of cancer tumors, checkpoint inhibitor immunotherapy remains foremost amongst unique therapeutic strategies being presently under research. A wide diversity in HDCT ended up being seen. Therefore, knowledge about the phenotype-genotype correlatio