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Because activating NEP was once reported to mitigate several airway inflammatory conditions; this review completely talks about the recommended NEP-based therapeutic properties of roflumilast, which may be of good value in curing COVID-19. But, additional clinical scientific studies are required to verify this strategy and to assess its in vivo preventive and healing efficacy against COVID-19.Neuropathic discomfort is a vital burdensome problem because o