https://www.selleckchem.com/pr....oducts/Staurosporine
SEC and AUC showed that the C172D and C172W mutants are also weaker decamers than wild-type and small-angle X-ray scattering analysis indicated greater flexibility with partially unstructured regions consistent with C-terminal unfolding. We propose that these structural changes around C172 negatively impact the active site geometry to decrease reactivity with H2O2. This is relevant for Prdx turnover as intermediate mixed disulfides with C172 would also be disruptive, and could potentially react with peroxides before resolution is
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