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Medication For ADHD - What Are the Side Effects? Many people suffering from ADHD notice a decrease in symptoms when they use medication. But each person reacts differently to different drugs and the adverse effects can be a problem. Methylphenidate is a stimulant. It works by raising levels of a chemical in the brain that aids in controlling the attention span and behavior. Stimulant medications Stimulant medication can improve attention and concentration for 70 to 80% of children and adults that use it. They alter neurotransmitters, such as norepinephrine and dopami