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Nonetheless, whether and how the UPS adds to oligodendrocyte dysfunction and fix after white matter injury (WMI) continues to be undefined. Right here we show that the E3 ligase VHL interacts with Daam2 and their particular shared antagonism regulates oligodendrocyte differentiation during development. Making use of proteomic evaluation regarding the Daam2-VHL complex in conjunction with conditional genetic knockout mouse models, we further discovered that the E3 ubiquitin ligase Ned