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46 mmHg [95%CI -2.63, -0.28; P = 0.01]) with no heterogeneity (P = 0.46; I = 0%). Serum lipopolysaccharide-binding protein (LBP) significantly decreased with antibiotics, but with high heterogeneity (P0.001; I = 92%). Rifaximin or norfloxacin did not significantly reduce HVPG in patients with cirrhosis and portal hypertension. Studies using antibiotic for longer periods on top of NSBB showed a significant decrease in HVPG. Rifaximin or norfloxacin did not significantly reduce HVPG in patients with cirrhosis and portal hypertension.