https://bgb15025inhibitor.com/....t1143-essential-for-
Inhibitor 17 had been a potent and isoform selective JNK3 inhibitor (IC50 = 35 nM), had considerable inhibition to just JNK3 in a panel profiling of 374 wild-type kinases, had high potency in practical cell-based assays, had large stability in peoples liver microsome (t1/2 = 66 min) and a clear CYP-450 inhibition profile, and had been orally bioavailable and brain penetrant. Moreover, cocrystal structures of compounds 17 and 27 in real human JNK3 were solved at 1.84 Å, which showed that these JNK3
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