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number ChiCTR1800019064. Name of trial registration Identify and the optimization of treatment for non-infectious chronic diseases under the "stress-dysrhythmia" theory hypothesis (Registration date 24/10/2018). The full trial protocol can be accessed at the Chinese Clinical Trial Registry ( http//www.chictr.org.cn/ ). Though circular RNAs (circRNAs) are the key regulators in tumor carcinogenesis, they remain largely unexplored in hepatocellular carcinoma (HCC). The expression of RanGAP1-derived circRNAs (circ_0063531, circ_0063534, circ
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