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We analyzed 1,321 RNA-Seq libraries of various mouse cells and cellular lines, comprising more than 6.6 TB sequences from 75 independent studies that experimentally controlled 56 splicing elements. Making use of these information, RNA splicing signatures and gene phrase signatures were computed, and signature contrast evaluation identified a summary of key splicing aspects in Rett problem and cold-induced thermogenesis. We show that cold-induced RNA-binding proteins rescue the neurite outgrowth pro