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Future research should replicate this study with a focus on the impact of the not proven verdict in sexual offences. Despite widespread adoption of potent acid suppression treatment with proton pump inhibitors (PPI) for reflux-like symptoms, persistent symptoms are commonly reported in primary care and community studies. This multidisciplinary review critically evaluates how the management of reflux-like symptoms could better reflect their multifactorial pathophysiology. A panel of experts (from general practice, gastroenterology and ga