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654, 0.786, 0.834, respectively. LRM4 was accurate even after limiting cases to early-stage HCC. LRM4 was proved useful in prompting clinicians to perform timely image study in the surveillance. The retroactive validation scheme is applicable to assess diagnostic models of other neoplastic diseases. LRM4 was proved useful in prompting clinicians to perform timely image study in the surveillance. The retroactive validation scheme is applicable to assess diagnostic models of other neoplastic diseases.Sepsis, which includes infection foll