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The Most Effective ADHD Medication For Adults The majority of ADHD medications fall into two categories: stimulants or non-stimulants. stimulants like methylphenidate and amphetamines stimulate brain areas that regulate attention and behavior. Non-stimulants, such as guanfacine the atomoxetine and clonidine work slower than stimulants, however they can help improve concentration and attention, as well as impulsivity. They also appear to decreas