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No correlations were found between the abnormal thalamo-cortical connectivity and clinical symptoms in either patient group. LIMITATION Most patients in our study were taking drugs at the time of scanning, which may confound our findings. CONCLUSION Our finding suggest that the thalamo-cortical hypofunction is a common neuro-substrate for BDD and MDD. Specifically, the hypoconnectivity between the thalamus and salience network including the insula, ACC and striatum may be a distinguished biomarker for MDD, which may help to differentiat