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01) and hemorrhage (p less then 0.01), decreased the production of the proinflammatory cytokines IL-1β (p less then 0.01), TNF-α (p less then 0.01) and IL-6 (p less then 0.05), and increased the anti-inflammatory cytokine IL-10 at the contusion site (p less then 0.01). Moreover, HCA administration reduced BBB disruption by regulating expression of tight junction proteins, including ZO-1, occludin and claudin-5 (ps less then 0.01). Together, our results demonstrate that HCA might have therapeutic efficacy in acute TBI, suggesting a poten