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Cytokine polymorphismsmight influence the predisposition to diabetic nephropathy (DN), but the results of already published related studies are still controversial and ambiguous. The authors designed this meta-analysis to more precisely estimate relationships between TNF-α/IL-1/IL-4/IL-8/IL-18polymorphisms and DN by pooling the results of already published related studies. The authors searched Pubmed, Embase, Web of Science and CNKI for already published studies. Thirty already published studies were pooled and analyzed in this meta-an