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How a VC Can Affect Your Heart Many people experience occasional PVCs with no problems. If occur often, PVCs may weaken your heart and increase the chance of suffering from heart failure. A bundle of fibers located in the upper right-hand corner of your heart (the sinoatrial, or SA, node) typically regulates the heart's rhythm. Electrical signals are transmitted to the ventricles or lower chambers of your heart. Causes PVCs are caused when the electrical impulse that typically initiates your heartbeat in a region known as