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Long non-coding RNAs (lncRNAs) are recognized to participate in HSCC development, as the role of lncRNA MALAT1 in HSCC stays largely unknown. We aimed to explore purpose of the lncRNA MALAT1/miR-429/ZEB1 axis in HSCC progression. Amounts of MALAT1, miR-429 and ZEB1 in HSCC tissues samples had been assessed. The FaDu cells had been respectively treated with relative sequence or plasmid of MALAT1, miR-429, or ZEB1. Then, CCK-8 assay, colony development assay, movement cytometry and Transwell assa