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Thus, researchers are recommended to conduct kinetic evaluations of lignin-first catalysts using biomass particles smaller than ~0.2 mm in length to avoid feedstock-specific mass transfer limitations in lignin conversion studies. Overall this work highlights opportunities to improve lignin solvolysis via genetic engineering and provides actionable kinetic information to guide the design and scale-up of emerging biorefinery strategies. © 2020 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim.Lupus miliaris disseminatus faciei (LMDF) is a r