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In the surviving patients, the viral load was significantly inversely correlated with SARS-CoV-2-specific IFNγ CD8 and IFNγ CD4 T cells, IgG, IgM, and IgA. T lymphopenia is common in critical or severe COVID-19 cases with hypertension. Prolonged activation and exhaustion of CD8 T cells were associated with severe disease. The delayed SARS-CoV-2-specific antibody responses may be insufficient for overcoming severe SARS-CoV-2 infection in the absence of SARS-CoV-2-specific cellular responses. T lymphopenia is common in critical or severe