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The hybrid composites exhibited reproducible, uniform tumefaction spheroids with a Z-depth of ∼65 ± 2 μm in case of individual adenocarcinoma (DLD-1) and ∼54 ± 3 μm for peoples glioblastoma cells (U-251) (vs. nonuniform spheroids, on Agarose matrix). Thereafter, their capacity for anticancer medication evaluating was examined making use of minimal cancer medicines. The conflicting drug testing outcomes for Etoposide's decreased effectiveness on glioblastoma cells cultured on our 3D matrix could b