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Finding the Best Medication For ADHD The most frequently prescribed medication for ADHD is stimulants. They include methylphenidates and amphetamines. Short-acting stimulants start working in under an hour and must be taken multiple times throughout the day. Long-acting stimulants can last for up to 16 hours and are typically taken only a few times per day. Your doctor may prescribe antidepressants or other types of medications "off-label" to trea