https://www.selleckchem.com/
Duloxetine has been recently used as a part of multimodal analgesia in perioperative settings, yet the optimal dose of Duloxetine is not determined. A parallel, randomized, placebo-controlled trial. Tertiary level oncology center. 88 female patients with breast cancer were subjected to modified radical mastectomy (MRM) with ASA class I and II were recruited. Participants were randomly allocated into 4 equal groups received 2h preoperatively, placebo (D0, N=22), Duloxetine 30mg (D30, N=22), Duloxetine 60mg (D60, N=22) and Duloxetine 90mg (D90, N=22) tablet.
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