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To characterize the cardiovascular effects of increasing dosages of norepinephrine (NE) in healthy isoflurane-anesthetized rabbits. Prospective experimental study. A total of nine female ovariohysterectomized New Zealand White rabbits weighing 3.4 ± 0.2 kg (mean ± standard deviation). Rabbits were premedicated intramuscularly with buprenorphine (0.05 mg kg ) and midazolam (0.5 mg kg ). Anesthesia was induced with intravenous propofol and maintained with a 1.1× minimum alveolar concentration of isoflurane for this species to induce hypot