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multaneously delivered CFM-4.16 and S0456 parenterally with selective tumor targeting, prolonged circulation, minimized off-target distribution.Introduction Lymphedema is a specific type of edema that affects regions of the body in a chronic, progressive manner. Aim The aim of the present study was to describe the therapeutic evolution of more than ten years of treatment for primary congenital lymphedema using the Godoy and Godoy method. Method Ten children with primary congenital lymphedema with more than ten years of treatment at th