https://www.selleckchem.com/products/kpt-330.html
Acetaminophen, a non-mutagenic compound as previously concluded from bacteria, in vitro mammalian cell and in vivo transgenic rat assays, presented a good profile as a negative mutagenic reference compound for use in the international multi-laboratory Pig-a assay validation. Acetaminophen was administered at 250, 500, 1,000, and 2000 mg/kg/day to male Sprague Dawley rats once daily in 3 studies (3 days, 2 weeks, and 1 month with a 1-month recovery group). The 3-Day and 1-Month Studies included assessments of the micronucleus endpoint in
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