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6±17.1 points at 24months. The multivariable linear models described the QOL points subtracted for each toxicity and symptom after radiotherapy. For example, xerostomia and weight loss had a significant but minor effect (on average -0.5 and -0.6 points) while speech problems and fatigue had a much greater impact (on average -11.9 and -17.4 points) on QOL. R goodness-of-fit values for the QOL models ranged from 0.64 (6months) to 0.72 (24months). The relative impact of physician-rated toxicities and patient-rated symptoms on QOL