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The difference between the experimental and control groups was significant (P=0.005). ATO has the ability to inhibit the growth and proliferation of RPE cells by regulating the expression of the ECM components' p27 and PCNA, in a time- and dose-dependent manner. Thus, ATO may lead to an innovative method for the treatment of proliferative retinopathy. IJCEP Copyright © 2020.Non-small cell lung cancer (NSCLC) is one of the most common causes of tumor-associated mortality worldwide. Early diagnosis is the key focus for improving progno