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We determined the incidence of hypercapnia and associations with outcome in invasively ventilated COVID-19 patients. Posthoc analysis of a national, multicenter, observational study in 22 ICUs. Patients were classified as 'hypercapnic' or 'normocapnic' in the first three days of invasive ventilation. Primary endpoint was prevalence of hypercapnia. Secondary endpoints were ventilator parameters, length of stay (LOS) in ICU and hospital, and mortality in ICU, hospital, at day 28 and 90. Of 824 patients, 485 (58.9%) were hypercapnic. Hyper
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