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Treating ADHD Without Medication Many people with ADHD find it effective to manage their symptoms without medication. Combining psychotherapy, behavior modification and natural remedies is often the best solution. Certain medications like methylphenidate boost brain chemicals that control attention and impulses. Nonstimulants like Guanfacine or atomoxetine, are also available. Exercise, psychotherapy and healthy sleeping habits can also aid. Some people with ADHD