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Cysteine is a versatile amino acid for selective chemical modification of proteins with both chemical and biological innovations, which plays a key role in different organic reactions. Chemical modification of proteins is a rapidly expanding area in chemical biology. Selective installation of biochemical probes has led to a better understanding of natural protein modification and macromolecular function. In other cases, such as chemical alterations, the protein function has entirely changed. This review paper considers the organic react
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