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ADHD Medications For Adults Stimulants can help regulate levels of chemical messengers in the brain, which control attention. They are first-line medications in the treatment of ADHD. Although they're not to be taken regularly, they can have adverse effects like headaches and difficulty sleeping. To decrease impulsivity or hyperactivity the doctor could prescribe guanfacine under the brand names Tenex or Intuniv (Catapres). These drugs have a longer duration of acti