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Indeed, in genomes where genes for small subunits were absent, we observed statistically significant enrichment of programmed frameshifting signals in chlD genes. Interestingly, the details of the frameshifting mechanisms producing small and medium subunits from a single chlD gene could be prokaryotic taxa specific. All over, this programmed frameshifting phenomenon was observed to be highly conserved and present in both bacteria and archaea. © The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Molecu