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BACKGROUND Several studies have shown an association of acne vulgaris with depression and anxiety but a quantitative review has not yet been conducted. OBJECTIVE To conduct a systematic review and meta-analysis that elucidates the association of acne vulgaris with depression and anxiety. METHOD A systematic review and meta-analysis of literature published prior to October 1, 2019 from PubMed, PsycINFO, MEDLINE, and Cochrane databases was conducted. We used a meta-analytic approach to perform a random effects analysis comparing individua