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han control group, and the levels of 5-HT and CRH in the heads of the larvae in the lead exposure groups of 24 and 48 μmol/L were higher than control group (P less then 0.05) . Conclusion Lead exposure is toxic to zebrafish embryonic development and may cause anxiety-like neurobehavior changes and oxidative stress in zebrafish.Objective To access the effects of evodiamine on carbon tetrachloride (CCl(4)) -induced liver fibrosis mice and study the mechanism based on modulating gut microbiota. Methods From August 2019, 30 SPF male C57BL/6 mi