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Background Bilateral cyclic high frequency deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) reduces the seizure count in a subset of patients with epilepsy. Detecting stimulation-induced alterations of pathological brain networks may help to unravel the underlying physiological mechanisms related to effective stimulation delivery and optimize target engagement. Methods We acquired 64-channel electroencephalography during ten ANT-DBS cycles (145Hz, 90μs, 3-5V) of 1-minute ON followed by 5-minutes OFF stimulation to