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Jose Lemme-Dumit works in the field of mucosal immunology and vaccines. In this mSphere of Influence article, he reflects on how two papers, "Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium" by Sato et al. (T. Sato, D. E. Stange, M. Ferrante, R. G. J. Vries, et al., Gastroenterology 1411762-1772, 2011, https//doi.org/10.1053/j.gastro.2011.07.05 and "T helper cell cytokines modulate intestinal stem cell renewal and differentiation" by Biton et al. (M. Biton, A. L. Haber, N.
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