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We also propose using descriptors scaled by the sum of #arn and #ban (SBAN) to define an antimalarial property space. Together, these results may have important applications in the identification and optimization of future antimalarials.Human immunodeficiency virus type 1 (HIV-1) is mainly transmitted by sexual intercourse, and effective microbicides preventing HIV-1 transmission are still required. Amphibian skin is a rich source of defense peptides with antiviral activity. Here, we characterized a lectin-like peptide, fejerlectin (RLC