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UA also reduced the EPS synthesis of oral streptococci and suppressed gtf genes' expression. In addition, UA reduced the proportion of S. mutans in multi-species biofilms. Besides, UA had low cytotoxicity against HOKs and HGEs. UA exhibited antibiofilm activity against oral pathogenic bacteria and had the potential to be used in dental caries treatment. UA exhibited antibiofilm activity against oral pathogenic bacteria and had the potential to be used in dental caries treatment.Relatively little work has been done on the role of micronu