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© 2020 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http//creativecommons.org/licenses/by/4.0/).BACKGROUND/PURPOSE Although illicit substance use-induced toxicity or complication is a frequent cause of visit to the emergency department (ED), there are limited data on cases confirmed by liquid chromatography tandem-mass spectrometry (LC-MS/MS) analysis. This study aimed to describe clinical presentations of patients who visited the ED because of acute illicit substance-related complica