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05). The escin postconditioning group also showed significantly higher LC3II expression and lower p62 expression levels than the control group ( 0.05). Escin can alleviate chemotherapy-induced peripheral neuropathic pain in rats possibly by upregulating the expressions of autophagy-related proteins in the spinal cord. Escin can alleviate chemotherapy-induced peripheral neuropathic pain in rats possibly by upregulating the expressions of autophagy-related proteins in the spinal cord. To investigate the effect of miR-324-5p on the