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Three hundred forty subjects were analyzed, all of which used amoxicillin. There were 106 cases in 24h group and 234 cases in 48h group. The total incidence of SSI was 1.1% (4/340 cases), with 0.9% (1/106 cases) in 24h group and 1.3% (3/234 cases) in 48h group; there was no difference between the two groups. Our study suggests that amoxicillin (250 mg/dose every 8h x 3 doses beginning 1h before surgery) might be sufficient in preventing SSI in Japanese dental patients without SSI risk factors. Our study suggests that amoxicillin (250 mg