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27 [0.10, 0.77], I 0%) and gastrointestinal bleeding (OR 0.31 [0.11, 0.88], I 0%) were lower in paracetamol group. Subgroup analysis of randomized controlled studies (RCTs) showed similar results. Meta-regression analysis showed that the primary closure rate was not influenced by gestational age, birth weight, and gender. GRADE demonstrates a low level of certainty for primary closure and mortality. Renal dysfunction and gastrointestinal bleeding havea moderate level of certainty. There was no significant difference between the efficacy of
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