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ADHD Treatment For Adults stimulants such as amphetamine and methylphenidate can boost the levels of certain brain chemicals. Nonstimulants, like atomoxetine and antidepressants, operate more slowly than stimulants but can also be beneficial. The comorbidity of conditions can influence the response to ADHD medication. Physicians should treat the most severe symptom of any comorbid disorder first, then monitor whether the ADHD symptoms improve.