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Twitter has emerged as a novel way for physicians to share ideas and advocate for policy change. #thisisourlane (firearm injury) and #getusppe (COVID-19) are examples of nationwide health care-led Twitter campaigns that went viral. Health care-initiated Twitter hashtags regarding major public health topics have gained national attention, but their content has not been systematically examined. We hypothesized that Twitter discourse on two epidemics (firearm injury and COVID-19) would differ between tweets with health care-initiated hash