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Finding the Best ADHD Medication For Adults Stimulants like methylphenidate or amphetamine, (Vyvanse), quickly work to regulate brain chemicals. These drugs can cause weight changes, tics, and sleep problems in some people. Atomoxetine and some antidepressants (like bupropion) are nonstimulant medications which work slowly to aid those suffering from ADHD symptoms. They boost a chemical in the brain called norepinephrine to improve concentration and control impulses. Stimulants ADHD med